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In single dose and short-term diet studies, lactating cows eliminated aldicarb metabolites as rapidly as rats and in the same array of metabolites. Approximately 1% of the dose was excreted in the milk, sulfone and sulfoxide were the major metabolites at 15 and 4% of the total milk residue content respectively. ...read more

 

Modeling the tumor immune microenvironment for drug

5/20/2020 · An engineered single-chain PD1 blocker has also demonstrated similar enhanced efficacy to second-generation CAR T cells with solely a CD28 domain 172. Even though CAR T cells are typically ...read more

 

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5/13/2019 · TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate TGF-β1–mediated fibrotic responses have not been defined. Here, we demonstrate that CHIT1 enhances TGF-β1–stimulated fibrotic cellular and tissue responses and TGF-β1 signaling. ...read more

 

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2/2/2021 · Macrophages exhibit the most similarity to adherent cells in their migration. Macrophages can migrate in an ameboid manner, where they take on a rounded morphology and migrate at higher speeds (approaching 1.0 μm/min) independent of proteolytic activity and minimally relying on … ...read more

 

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12/2/2020 · A Global Career in Experimental Physics The award recognises the physicist’s outstanding experimental work in terahertz and solid-state physics at the interface between optics and electronics. Huber, who grew up in Upper Bavaria near lake Chiemsee, earned his doctorate in 2003 at the Technical University of Munich. ...read more

 

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8/24/2020 · Liver and kidney tissue was homogenized with a metal spatula. The amphipod samples were crushed and simultaneously homogenized in a ceramic mortar with ceramic pestle (Bauscher, Weiden, Germany). Sample weight for fish muscle, liver and kidney was 1 g and for the amphipods 0.25 g per sample. All samples underwent a single determination. ...read more

 

Single strand consensus sequencing reveals that HIV type

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Chitinase 1 regulates pulmonary fibrosis by modulating TGF

10/30/2001 · A single band representing approximately 98% of total incorporated radioactivity corresponded to the m.w. of the scFv molecule (28 kDa) and was detected by SDS‐PAGE (Fig. 3b). The scFvs, after radiolabeling, were analyzed by HPLC (Fig. 4). The CC49 scFv forms eluted as single peaks without any detectable aggregates, suggesting they were not ...read more

 

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1/28/2021 · Single-crystal (SC) NMR spectroscopy is a solid-state NMR method that has been used since the early days of NMR to study the magnitude and orientation … ...read more

 

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7/21/2017 · Introduction. Human immunodeficiency virus type-1 (HIV-1) has typically been found to mutate on the order of 10 −4 –10 −5 (average of ~3.6×10 −5) mutations/base pair/cycle (m/bp/c) in cells [1–4], a rate approximately 10,000–100,000 times faster than eukaryotic genomic DNA [].The fidelity of HIV-1 replication can be modulated by a variety of viral and cellular factors. ...read more

 

In the Enchanting Land of Zoigl Beer • A Tempest in a Tankard

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Lung and gut microbiota are altered by hyperoxia and

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